Celontin and Divalproex

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Methsuximide may reduce the blood levels and effects of divalproex sodium. You may need a dose adjustment if you have been receiving divalproex sodium and are starting treatment with methsuximide. Likewise, if you have been receiving both medications, the dose of divalproex sodium may need to be adjusted if methsuximide is discontinued. Contact your doctor if you experience loss of seizure control or increased side effects during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with methsuximide may decrease the plasma concentrations of valproic acid. The exact mechanism of interaction is unknown. The interaction was reported in a study of pediatric patients ranging in age from 8 to 19 with epilepsy. In eight patients who had been receiving valproic acid with methsuximide, mean valproic acid serum level increased by 44% following the discontinuation of methsuximide. In 14 patients who had methsuximide added to stable valproic acid therapy, mean valproic acid serum level decreased by 32% following the addition of methsuximide.

MANAGEMENT: Caution is advised if methsuximide and valproic acid are used in combination. Pharmacologic response and serum valproic acid level should be monitored more closely whenever methsuximide is added to or withdrawn from stabilized therapy, and the dosage(s) of the drugs adjusted as necessary.

Celontin

Generic Name: methsuximide

Brand name: Celontin

Synonyms: n.a.

What is Celontin?

Divalproex

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakote, Depakene, Depacon

Synonyms: Divalproex sodium

What is Divalproex?