Celontin Kapseals and Depakote ER
Determining the interaction of Celontin Kapseals and Depakote ER and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Methsuximide may reduce the blood levels and effects of divalproex sodium. You may need a dose adjustment if you have been receiving divalproex sodium and are starting treatment with methsuximide. Likewise, if you have been receiving both medications, the dose of divalproex sodium may need to be adjusted if methsuximide is discontinued. Contact your doctor if you experience loss of seizure control or increased side effects during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with methsuximide may decrease the plasma concentrations of valproic acid. The exact mechanism of interaction is unknown. The interaction was reported in a study of pediatric patients ranging in age from 8 to 19 with epilepsy. In eight patients who had been receiving valproic acid with methsuximide, mean valproic acid serum level increased by 44% following the discontinuation of methsuximide. In 14 patients who had methsuximide added to stable valproic acid therapy, mean valproic acid serum level decreased by 32% following the addition of methsuximide.
MANAGEMENT: Caution is advised if methsuximide and valproic acid are used in combination. Pharmacologic response and serum valproic acid level should be monitored more closely whenever methsuximide is added to or withdrawn from stabilized therapy, and the dosage(s) of the drugs adjusted as necessary.
- Besag FM, Berry DJ, Vasey M "Methsuximide reduces valproic acid serum levels." Ther Drug Monit 23 (2001): 694-7
Generic Name: methsuximide
Brand name: Celontin
Synonyms: Celontin
Generic Name: divalproex sodium
Brand name: Depakote ER, Depakote Sprinkles, Depakene, Depacon, Depakote
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Celontin Kapseals-Depakote Pellets
- Celontin Kapseals-Depakote Sprinkles
- Celontin Kapseals-Depen
- Celontin Kapseals-Depen Titratabs
- Celontin Kapseals-Deplin
- Celontin Kapseals-Deplin 15
- Depakote ER-Cemill
- Depakote ER-Cemill 1000
- Depakote ER-Cemill 500
- Depakote ER-Cenafed
- Depakote ER-Cenestin Oral
- Depakote ER-CenFol