Cerebyx and Flagyl 375

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before taking metroNIDAZOLE, tell your doctor if you also use fosphenytoin. You may need dose adjustments or special tests in order to safely take both medications together. The combination may increase fosphenytoin levels. You should notify your doctor if you have symptoms such as drowsiness, vision problems, changes in behavior, nausea, or poor muscle coordination. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

MONITOR: Coadministration with a nitroimidazole may increase the serum concentrations of phenytoin. The interaction has been reported with metronidazole, and the proposed mechanism is inhibition of phenytoin metabolism via CYP450 2C9. In one study, metronidazole (250 mg orally three times a day for 4 days) increased the half life of phenytoin (300 mg single intravenous dose) in healthy volunteers by 44% and reduced its clearance by 15% compared to control values. However, another study found no effect of metronidazole (400 mg orally twice a day) on the pharmacokinetics of orally administered phenytoin (300 mg single dose). No data are available for tinidazole.

MANAGEMENT: Pharmacologic response and serum phenytoin levels should be monitored more closely whenever metronidazole is added to or withdrawn from therapy, and the phenytoin (or fosphenytoin) dosage adjusted as necessary. Patients should be advised to notify their physician if they experience potential symptoms of phenytoin toxicity such as nausea, vomiting, nystagmus, slurred speech, lethargy, tremor, ataxia, hyperreflexia, and dysarthria. Given its structural similarities to metronidazole, the same precaution may be applicable during therapy with tinidazole, although clinical data are lacking.

Cerebyx

Generic Name: fosphenytoin

Brand name: Cerebyx

Synonyms: n.a.

What is Cerebyx?

Flagyl 375

Generic Name: metronidazole

Brand name: FIRST Metronidazole, Flagyl, Flagyl 375, MetroGel

Synonyms: Flagyl 375 Capsules

What is Flagyl 375?