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Cerebyx and Prestalia

Determining the interaction of Cerebyx and Prestalia and the possibility of their joint administration.

Check result:

Cerebyx <> Prestalia

Relevance: 21.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using amLODIPine together with fosphenytoin may increase the effects of fosphenytoin. You should notify your doctor if you have symptoms such as drowsiness, visual disturbances, seizures, changes in behavior, nausea, or poor muscle coordination. You may need dose adjustments or special tests in order to safely use both medications together. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.

Professional:

MONITOR: Diltiazem and verapamil may increase plasma phenytoin levels. Toxicity has been reported. The proposed mechanism is inhibition of CYP450 3A4 metabolism. In addition, phenytoin may significantly decrease calcium channel blocker (CCB) serum levels by inducing first-pass metabolism and the systemic clearance. Other hydantoins may participate in these interactions as well.

MANAGEMENT: Close clinical and laboratory observation for evidence of altered effect of both drugs is recommended if a CCB and a hydantoin must be used together. Patients should be advised to notify their physician if they experience symptoms of phenytoin toxicity (e.g., drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia) or loss of effect of their CCB.

References

Bahls FH, Ozuna J, Ritchie DE "Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin." Neurology 41 (1991): 740-2
Woodcock BG, Kirsten R, Nelson K, Rietbrock S, Hopf R, Kaltenbach M "A reduction in verapamil concentrations with phenytoin." N Engl J Med 325 (1991): 1179
Clarke WR, Horn JR, Kawabori I, Gurtel S "Potentially serious drug interactions secondary to high-dose diltiazem used in the treatment of pulmonary hypertension." Pharmacotherapy 13 (1993): 402-5
Michelucci R, Cipolla G, Passarelli D, Gatti G, Ochan M, Heinig R, Tassinari CA, Perucca E "Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy." Epilepsia 37 (1996): 1107-10
Ahmad S "Nifedipine-phenytoin interaction." J Am Coll Cardiol 3 (1984): 1582
Bahls FH, Ozuna J, Ritchie DE "Interactions between calcium channel blockers and the anticonvulsants carbamazepine and phenytoin." Neurology 41 (1991): 740-2
Capewell S, Critchley JA, Freestone S, Pottage A, Prescott LF "Reduced felodipine bioavailability in patients taking anticonvulsants." Lancet 2 (1988): 480

Cerebyx

Generic Name: fosphenytoin

Brand name: Cerebyx

Synonyms: n.a.

What is Cerebyx?

Prestalia

Generic Name: amlodipine / perindopril

Brand name: Prestalia

Synonyms: n.a.

What is Prestalia?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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