Cerezyme and Typhoid vi polysaccharide vaccine Intramuscular

• Generic Name: imiglucerase
• Dosage Forms: injection, powder, lyophilized, for solution
• Other Brand Names: Cerezyme

Cerezyme (imiglucerase) is a man-made form of an enzyme that occurs naturally in the body. It is used as an enzyme replacement in people with Type I Gaucher disease.

Gaucher disease is a genetic condition in which the body lacks the enzyme needed to break down certain fatty materials (lipids). Lipids can build up in the body, causing symptoms such as easy bruising or bleeding, weakness, anemia, bone or joint pain, enlarged liver or spleen, or weakened bones that are easily fractured.

Cerezyme may improve the condition of the liver, spleen, bones, and blood cells in people with Type I Gaucher disease. However, this medicine is not a cure for this condition.

Cerezyme may also be used for purposes other than those listed in this medication guide.

• Generic Name: typhoid vaccine, inactivated
• Dosage Forms: n.a.
• Other Brand Names: Typhim VI

Typhoid fever is a serious disease that can cause death. It is caused by a germ called Salmonella typhi, and is spread most often through infected food or water. Typhoid may also be spread by close person-to-person contact with infected persons (such as occurs with persons living in the same household). Some infected persons do not appear to be sick, but they can still spread the germ to others.

Typhoid fever is very rare in the U.S. and other areas of the world that have good water and sewage (waste) systems. However, it is a problem in parts of the world that do not have such systems. If you are traveling to certain countries or remote, out-of-the-way areas, typhoid vaccine will help protect you from typhoid fever. The U.S. Centers for Disease Control (CDC) currently recommend caution in the following areas of the world:

• Africa
• Asia
• Latin America

Typhoid vaccine given by injection helps prevent typhoid fever, but does not provide 100% protection. Therefore, it is very important to avoid infected persons and food and water that may be infected, even if you have received the vaccine.

To get the best possible protection against typhoid, you should receive the vaccine at least 1 week before you travel to areas where you may be exposed to typhoid.

If you will be traveling regularly to parts of the world where typhoid is a problem, you should get a booster (repeat) dose of the vaccine every 2 years.

Typhoid vaccine is to be used only by or under the supervision of a doctor.