Ceritinib and Vorapaxar Sulfate
Determining the interaction of Ceritinib and Vorapaxar Sulfate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of vorapaxar, which is a substrate of the isoenzyme. When vorapaxar was coadministered with ketoconazole 400 mg, mean vorapaxar peak plasma concentration (Cmax) and systemic exposure (AUC) increased by nearly 2-fold. MANAGEMENT: Concomitant use of vorapaxar with potent CYP450 3A4 inhibitors should generally be avoided. References "Product Information. Zontivity (vorapaxar)." Merck & Company Inc, Whitehouse Station, NJ.
Professional:GENERALLY AVOID: Coadministration with potent inhibitors of CYP450 3A4 may significantly increase the plasma concentrations of vorapaxar, which is a substrate of the isoenzyme. When vorapaxar was coadministered with ketoconazole 400 mg, mean vorapaxar peak plasma concentration (Cmax) and systemic exposure (AUC) increased by nearly 2-fold.
MANAGEMENT: Concomitant use of vorapaxar with potent CYP450 3A4 inhibitors should generally be avoided.
- "Product Information. Zontivity (vorapaxar)." Merck & Company Inc, Whitehouse Station, NJ.
Generic Name: vorapaxar
Brand name: Zontivity
Synonyms: Vorapaxar
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Ceritinib-Voraxaze
- Ceritinib-Voriconazole
- Ceritinib-Voriconazole Injection
- Ceritinib-Voriconazole Oral, Intravenous
- Ceritinib-Voriconazole oral/injection
- Ceritinib-Voriconazole Suspension
- Vorapaxar Sulfate-Cerovite Jr
- Vorapaxar Sulfate-Certolizumab
- Vorapaxar Sulfate-Certolizumab Pegol
- Vorapaxar Sulfate-Certolizumab Prefilled Syringes
- Vorapaxar Sulfate-Certolizumab Subcutaneous
- Vorapaxar Sulfate-Certolizumab Vials