Certolizumab Prefilled Syringes and Pegvaliase-pqpz Subcutaneous

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Pegvaliase may cause severe allergic reactions, and using it together with other "PEGylated" medications (i.E., medications formulated with polyethylene glycol) may increase the risk. Some examples of PEGylated medications besides pegvaliase include: certolizumab pegol (Cimzia); doxorubicin liposomal (Doxil, Lipodox); epoetin beta-methoxy polyethylene glycol (Mircera); medroxyprogesterone acetate injectable suspension (Depo-Provera); naloxegol (Movantik); pegademase bovine (Adagen); pegaptanib (Macugen); pegaspargase (Oncaspar); pegfilgrastim (Neulasta, Fulphila); peginesatide (Omontys); peginterferons (Pegasys, PEG-Intron, Sylatron, Plegridy); pegloticase (Krystexxa); pegvisomant (Somavert); and certain recombinant products used to treat hemophilia (Adynovate, Rebinyn). Before receiving treatment with pegvaliase, let your doctor know if you are currently using other PEGylated products. Your doctor will prescribe an auto-injectable epinephrine for you (or your caregiver) to administer in case you experience a severe allergic reaction during treatment with pegvaliase. You should stop using pegvaliase and seek immediate medical attention if you develop any of the following symptoms of a severe allergic reaction: fainting; dizziness or lightheadedness; sudden confusion; trouble breathing or wheezing; chest discomfort or tightness; rapid heart rate; swelling of your face, lips, eyes, or tongue; throat tightness; flushing; rash, itching, or raised bumps on skin; nausea, vomiting, or diarrhea; and incontinence. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of pegvaliase with other PEGylated products may increase the risk of hypersensitivity reactions, including anaphylaxis. In a single-dose study of pegvaliase in adults with phenylketonuria, two patients experienced hypersensitivity reactions during concomitant injections of medroxyprogesterone acetate suspension, a formulation containing PEG 3350. The first patient experienced a hypersensitivity reaction on day 15 after a single 0.67 mg dose of pegvaliase within 15 minutes following medroxyprogesterone acetate injection, and subsequently experienced anaphylaxis on day 89 within 30 minutes after the next dose of medroxyprogesterone acetate injection. The second patient experienced a hypersensitivity reaction on day 40 after a single 0.08 mg dose of pegvaliase within 10 minutes following medroxyprogesterone acetate injection. Both patients had high anti-PEG IgG antibody titers at or around the time of the hypersensitivity reactions. In clinical trials, the majority of patients developed anti-PEG IgM and IgG antibodies after treatment with pegvaliase. The clinical effects of concomitant treatment with different PEGylated products is unknown.

MANAGEMENT: Close monitoring for anaphylaxis and other hypersensitivity reactions is recommended during concomitant use of pegvaliase with other PEGylated products (e.g., certolizumab pegol; doxorubicin liposomal; epoetin beta-methoxy polyethylene glycol; medroxyprogesterone acetate suspension; naloxegol; pegademase bovine; pegaptanib; pegaspargase; pegfilgrastim; peginesatide; peginterferons; pegloticase; pegvisomant; certain formulations of recombinant antihemophilic factor and coagulation factor IX).

Certolizumab Prefilled Syringes

Generic Name: certolizumab

Brand name: Cimzia, Cimzia Starter

Synonyms: Certolizumab, Certolizumab Pegol

What is Certolizumab Prefilled Syringes?

Pegvaliase-pqpz Subcutaneous

Generic Name: pegvaliase

Brand name: Palynziq

Synonyms: Pegvaliase

What is Pegvaliase-pqpz Subcutaneous?