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Cevi-Bid and InnoPran XL

Determining the interaction of Cevi-Bid and InnoPran XL and the possibility of their joint administration.

Check result:

Cevi-Bid <> InnoPran XL

Relevance: 10.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data suggest that ascorbic acid may decrease the oral bioavailability of propranolol by possibly interfering with its absorption from the gastrointestinal tract. In 5 healthy subjects, pretreatment with a 2 gram dose of ascorbic acid 30 minutes before an 80 mg dose of propranolol decreased the peak plasma concentration (Cmax) and 24-hour area under the concentration-time curve (AUC) of propranolol by 28% and 37%, respectively, compared to when propranolol was administered alone. The time to reach maximum propranolol concentration (Tmax) was increased from 1.9 to 2.7 hours, and the total amount of drug (including metabolites) recovered in urine was significantly diminished. Although the heart rate decreased less during coadministration with ascorbic acid, the clinical significance is considered minor.

References

Gonzalez JP, Valdivieso A, Calvo R, Rodriquezsasiain JM, Jimenez R, Aguirre C, Dusouich P "Influence of vitamin c on the absorption and first pass metabolism of propranolol." Eur J Clin Pharmacol 48 (1995): 295-7

Cevi-Bid

Generic Name: ascorbic acid

Brand name: Cemill, Cevi-Bid, Acerola, Ascorbic Acid Quick Melts, C/Rose Hips, Cecon, Cemill 500, C-Time, Ester-C, N Ice with Vitamin C, Sunkist Vitamin C, Vasoflex HD, Vicks Vitamin C Drops, Vitamin C, Cenolate, Mega-C-Acid Plus, Cee-500, C-500-Gr, Centrum Singles-Vitamin C, Ascot, Vitamin C TR, Vitamin C with Rose Hips, Cemill 1000, Ascor L NC, Ascor, Ascor L 500, Betac, Protexin

Synonyms: n.a.

What is Cevi-Bid?

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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