Cevimeline Hydrochloride and Diphenhydramine Injection
Determining the interaction of Cevimeline Hydrochloride and Diphenhydramine Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:DiphenhydrAMINE may increase the blood levels of cevimeline. This can increase side effects such as nausea, vomiting, diarrhea, sweating, drooling, increased urination, blurred vision, confusion, tremor, heart palpitations, and irregular heartbeat. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inhibitors of CYP450 2D6 and/or 3A4 may increase the plasma concentrations of cevimeline, which is metabolized by these isoenzymes.
MANAGEMENT: Dosage adjustments and clinical monitoring may be appropriate whenever a CYP450 2D6 and/or 3A4 inhibitor is added to or withdrawn from therapy. Patients should be advised to notify their physician if they experience excessive adverse cholinergic effects of cevimeline such as nausea, vomiting, diarrhea, sweating, salivation, urinary frequency, visual disturbance, confusion, tremor, palpitations, or irregular heartbeat.
- "Product Information. Evoxac (cevimeline)" Daiichi Pharmaceuticals, Fort lee, NJ.
Generic Name: cevimeline
Brand name: Evoxac
Synonyms: Cevimeline
Generic Name: diphenhydramine
Brand name: Allergy Relief, Allermax, Banophen, Benadryl, Compoz Nighttime Sleep Aid, Diphedryl, Diphenhist, Dytuss, Nytol QuickCaps, PediaCare Children's Allergy, Q-Dryl, QlearQuil Nightitme Allergy Relief, Quenalin, Scot-Tussin Allergy Relief Formula, Siladryl Allergy, Silphen Cough, Simply Sleep, Sleepinal, Sominex, Tranquil, Twilite, Unisom Sleepgels Maximum Strength, Valu-Dryl, Vanamine PD, Z-Sleep, ZzzQuil, plus many others, Benadryl Allergy, Complete Allergy, Nytol, Unisom SleepMelts
Synonyms: Diphenhydramine, DiphenhydrAMINE (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cevimeline Hydrochloride-Diphenhydramine Injection Solution
- Cevimeline Hydrochloride-Diphenhydramine Oral Solution
- Cevimeline Hydrochloride-Diphenhydramine Oral Strips
- Cevimeline Hydrochloride-Diphenhydramine Suspension
- Cevimeline Hydrochloride-Diphenhydramine/Pseudoephedrine Tablets
- Cevimeline Hydrochloride-Diphenoxylate and atropine
- Diphenhydramine Injection-Chamomile
- Diphenhydramine Injection-Chantix
- Diphenhydramine Injection-Chantix Continuing Month Pak
- Diphenhydramine Injection-Chantix Start Month Pak
- Diphenhydramine Injection-Chantix Starter Pack
- Diphenhydramine Injection-Chantix Starting Month Box