Chantix Continuing Month Pak and Cimetidine Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with cimetidine has been shown to slightly increase the plasma concentrations of varenicline. The proposed mechanism is cimetidine inhibition of the active renal secretion of varenicline via human organic cation transporter, OCT2. When cimetidine (300 mg orally four times a day) was given with varenicline (2 mg single oral dose) to 12 smokers, the systemic exposure (AUC) of varenicline increased by 29%. This increase is not expected to be clinically relevant, and a dosage adjustment should not be necessary.

Chantix Continuing Month Pak

Generic Name: varenicline

Brand name: Chantix, Chantix Starter Pack, Chantix Continuing Month

Synonyms: Varenicline

What is Chantix Continuing Month Pak?

Cimetidine Tablets

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: Cimetidine

What is Cimetidine Tablets?