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Chenodal and Cholestyramine Resin

Determining the interaction of Chenodal and Cholestyramine Resin and the possibility of their joint administration.

Check result:
Chenodal <> Cholestyramine Resin
Relevance: 23.07.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Taking the chenodeoxycholic acid and cholestyramine doses too close together may interfere with the absorption of chenodeoxycholic acid and reduce its effectiveness. To prevent or minimize the interaction, chenodeoxycholic acid should be taken at least four hours before the cholestyramine dose. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: Bile acid sequestering agents may bind to and decrease the gastrointestinal absorption of chenodeoxycholic acid, which is a naturally occurring human bile acid.

MANAGEMENT: As with other drugs whose absorption may be reduced by bile acid sequestering agents, chenodeoxycholic acid should be administered at least 4 hours before the bile acid sequestering agent. However, adjusting the dosing interval may not completely prevent the interaction.

References
  • "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
  • "Product Information. Questran (cholestyramine)." Par Pharmaceutical Inc, Chestnut Ridge, NY.
  • "Product Information. Chenodal (chenodeoxycholic acid)." Manchester Pharmaceutical, Fort Collins, CO.
Chenodal

Generic Name: chenodeoxycholic acid

Brand name: Chenodal

Synonyms: n.a.

Cholestyramine Resin

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: Cholestyramine

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction