Chlophedianol, dexchlorpheniramine, and pseudoephedrine and Levoleucovorin Calcium

• Generic Name: chlophedianol / dexchlorpheniramine / pseudoephedrine
• Dosage Forms: n.a.
• Other Brand Names: Panatuss PED, Vanacof, Panatuss PED Drops

Chlophedianol is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Dexchlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Chlophedianol, dexchlorpheniramine, and pseudoephedrine is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, and sinus congestion caused by allergies, the common cold, or the flu.

chlophedianol, dexchlorpheniramine, and pseudoephedrine will not treat a cough that is caused by smoking, asthma, bronchitis, or emphysema.

Chlophedianol, dexchlorpheniramine, and pseudoephedrine may also be used for purposes not listed in this medication guide.

• Generic Name: levoleucovorin
• Dosage Forms: n.a.
• Other Brand Names: Fusilev, Khapzory

IV rescue therapy after high-dose methotrexate therapy (to control the duration of exposure of sensitive cells to methotrexate) for treatment of osteosarcoma (designated an orphan drug by FDA for this use).

Antidote to diminish the toxicity and counteract the effects of unintentional overdosage of methotrexate (e.g., resulting from impaired elimination) and other folic acid antagonists (designated an orphan drug by FDA for this use).

In combination with fluorouracil for the palliative treatment of advanced-stage colorectal cancer.

Has been studied for treatment of advanced-stage colorectal cancer in combination with fluorouracil and other agents (i.e., irinotecan, oxaliplatin). However, use in such combination regimens not fully established.

Manufacturer states that levoleucovorin should not be used for the treatment of pernicious anemia and megaloblastic anemias secondary to lack of vitamin B12; such use may alleviate hematologic manifestations while allowing neurologic complications to progress.