Chloral Hydrate Capsules and Jantoven

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with chloral hydrate can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Chloral hydrate may temporarily potentiate the hypoprothrombinemic effect of warfarin and similar anticoagulants. The mechanism is protein binding displacement by trichloroacetic acid, a major metabolite of chloral hydrate, resulting in increased plasma concentrations of unbound (active) anticoagulant drug. However, since drug clearance is also increased with higher levels of unbound drug, the pharmacokinetic effects produced by chloral hydrate tend to balance out over time, resulting in little or no net effect on anticoagulation therapy in the long-term. The manufacturer of triclofos cautions that it may also interact with anticoagulants.

MANAGEMENT: Based on these observations, appropriate monitoring for excessive hypoprothrombinemia (INR/PT) is recommended for several days following the addition of chloral hydrate or triclofos to a stabilized regimen of warfarin or other oral anticoagulants. Consideration may be given to using other sedative/hypnotic agents that have not been shown to interact with oral anticoagulants such as benzodiazepines or diphenhydramine. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

Chloral Hydrate Capsules

Generic Name: chloral hydrate

Brand name: Somnote

Synonyms: n.a.

What is Chloral Hydrate Capsules?

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?