Chloramphenicol Injection and Lapatinib Ditosylate
Determining the interaction of Chloramphenicol Injection and Lapatinib Ditosylate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Chloramphenicol may increase the blood levels and effects of lapatinib. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as diarrhea, nausea, vomiting, and fatigue. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of lapatinib, which is primarily metabolized by the isoenzyme. In healthy subjects, administration of lapatinib in combination with the potent inhibitor ketoconazole (200 mg twice daily for 7 days) resulted in lapatinib systemic exposure (AUC) and half-life that were approximately 3.6- and 1.7-fold, respectively, of the control values.
MANAGEMENT: Caution is advised when lapatinib is prescribed with CYP450 3A4 inhibitors. Pharmacologic response to lapatinib should be monitored more closely whenever a CYP450 3A4 inhibitor is added to or withdrawn from therapy, and the lapatinib dosage adjusted as necessary. Patients should be advised to contact their physician if they experience increased adverse effects of lapatinib such as diarrhea, nausea, vomiting, dyspepsia, and fatigue.
- "Product Information. Tykerb (lapatinib)." Novartis Pharmaceuticals, East Hanover, NJ.
Generic Name: chloramphenicol
Brand name:
Synonyms: Chloramphenicol, Chloramphenicol (Systemic)
Generic Name: lapatinib
Brand name: Tykerb
Synonyms: Lapatinib
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Chloramphenicol Injection-Lariam
- Chloramphenicol Injection-Larin 1.5/30
- Chloramphenicol Injection-Larin 1/20
- Chloramphenicol Injection-Larin 24 Fe
- Chloramphenicol Injection-Larin Fe 1.5/30
- Chloramphenicol Injection-Larin Fe 1/20
- Lapatinib Ditosylate-Chloramphenicol Ophthalmic
- Lapatinib Ditosylate-Chloramphenicol Oral, Intravenous, Injection
- Lapatinib Ditosylate-Chloramphenicol Otic
- Lapatinib Ditosylate-Chloramphenicol Sodium Succinate
- Lapatinib Ditosylate-Chloraseptic (Benzocaine and Menthol Lozenges)
- Lapatinib Ditosylate-Chloraseptic (Benzocaine and Menthol Strips)