Chloramphenicol Injection and Lopinavir and Ritonavir Oral Solution
Determining the interaction of Chloramphenicol Injection and Lopinavir and Ritonavir Oral Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 may increase the plasma concentrations of lopinavir, which is primarily metabolized by the isoenzyme. The magnitude and clinical significance of this interaction are unknown, particularly when in the presence of ritonavir as a pharmacokinetic booster. Limited data indicate that ketoconazole, a potent CYP450 3A4 inhibitor, does not substantially alter the plasma concentrations of lopinavir administered as lopinavir-ritonavir in a 4:1 ratio.
- "Product Information. Kaletra (lopinavir-ritonavir)" Abbott Pharmaceutical, Abbott Park, IL.
Generic Name: chloramphenicol
Brand name:
Synonyms: Chloramphenicol, Chloramphenicol (Systemic)
Generic Name: lopinavir / ritonavir
Brand name: Kaletra
Synonyms: Lopinavir and ritonavir, Lopinavir and Ritonavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Chloramphenicol Injection-Lopinavir and Ritonavir Solution
- Chloramphenicol Injection-Lopinavir and Ritonavir Tablets
- Chloramphenicol Injection-Lopreeza
- Chloramphenicol Injection-Lopressor
- Chloramphenicol Injection-Lopressor (Metoprolol Injection)
- Chloramphenicol Injection-Lopressor (Metoprolol Tablets)
- Lopinavir and Ritonavir Oral Solution-Chloramphenicol Ophthalmic
- Lopinavir and Ritonavir Oral Solution-Chloramphenicol Oral, Intravenous, Injection
- Lopinavir and Ritonavir Oral Solution-Chloramphenicol Otic
- Lopinavir and Ritonavir Oral Solution-Chloramphenicol Sodium Succinate
- Lopinavir and Ritonavir Oral Solution-Chloraseptic (Benzocaine and Menthol Lozenges)
- Lopinavir and Ritonavir Oral Solution-Chloraseptic (Benzocaine and Menthol Strips)