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Chloramphenicol Injection and Tacrolimus Oral, Intravenous

Determining the interaction of Chloramphenicol Injection and Tacrolimus Oral, Intravenous and the possibility of their joint administration.

Check result:

Chloramphenicol Injection <> Tacrolimus Oral, Intravenous

Relevance: 08.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using tacrolimus together with chloramphenicol may increase the effects of tacrolimus. Contact your doctor if you experience tremors, headache, fatigue, or lethargy. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited clinical data suggest that chloramphenicol may significantly increase tacrolimus blood concentrations. Inhibition of tacrolimus metabolism by chloramphenicol may be the mechanism of this interaction.

MANAGEMENT: Patients should be monitored for clinical and laboratory evidence of tacrolimus toxicity (nephrotoxicity and neurotoxicity) if chloramphenicol is to be added to or removed from the drug regimen. Patients should be advised to report symptoms such as tremors, headache, fatigue, or lethargy.

References

Schulman SL, Shaw LM, Jabs K, Leonard MB, Brayman KL "Interaction between tacrolimus and chloramphenicol in a renal transplant recipient." Transplantation 65 (1998): 1397-8
Taber DJ, Dupuis RE, Hollar KD, Strzalka AL, Johnson MW "Drug-drug interaction between chloramphenicol and tacrolimus in a liver transplant recipient." Transplant Proc 32 (2000): 660-2

Chloramphenicol Injection

Generic Name: chloramphenicol

Brand name:

Synonyms: Chloramphenicol, Chloramphenicol (Systemic)

What is Chloramphenicol Injection?

Tacrolimus Oral, Intravenous

Generic Name: tacrolimus

Brand name: Astagraf XL, Envarsus XR, Prograf, Hecoria

Synonyms: Tacrolimus (oral and injection), Tacrolimus (Systemic)

What is Tacrolimus Oral, Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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