Chloramphenicol Injection and Zinacef

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Chloramphenicol may diminish the effects of cefuroxime in the treatment of certain infections. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Limited, primarily in vitro, data suggest that chloramphenicol may antagonize the bactericidal activity of cephalosporins against certain clinical isolates of gram-negative rods, group B streptococci, and Staphylococcus aureus. This antagonism appears to occur against strains for which chloramphenicol is bacteriostatic, and has been demonstrated with cefoperazone, cefotaxime, and ceftriaxone. The proposed mechanism is inhibition of protein synthesis by chloramphenicol, resulting in less protein substrate for cephalosporins to act on as inhibitors of bacterial cell wall synthesis. The clinical relevance of these findings is unknown. Potential antagonism was suspected in two case reports of treatment failure in patients with gram-negative bacterial meningitis who received a cephalosporin in combination with chloramphenicol. One patient, a 2.5-month-old infant with Salmonella enteritidis group D meningitis, was subsequently treated with the cephalosporin (ceftazidime) alone and recovered uneventfully. The other, a 51-year-old male with Klebsiella pneumoniae meningitis, was subsequently treated with the cephalosporin (cefotaxime) plus amikacin and became afebrile, but later died with progressive neurologic disease. Autopsy findings were consistent with subacute spongiform encephalopathy (Creutzfeldt-Jakob disease).

MANAGEMENT: The manufacturers recommend to avoid concomitant use . However, if concurrent administration cannot be avoided, the possibility of antagonism should be considered, and patients should be monitored for altered therapeutic effect.

Chloramphenicol Injection

Generic Name: chloramphenicol

Brand name:

Synonyms: Chloramphenicol, Chloramphenicol (Systemic)

What is Chloramphenicol Injection?

Zinacef

Generic Name: cefuroxime

Brand name: Zinacef, Ceftin, Kefurox, Zinacef ADD-Vantage, Zinacef TwistVial

Synonyms: n.a.

What is Zinacef?