Chloramphenicol Oral, Intravenous, Injection and Hydroxocobalamin Injection (Cyanide Poisoning)
Determining the interaction of Chloramphenicol Oral, Intravenous, Injection and Hydroxocobalamin Injection (Cyanide Poisoning) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Chloramphenicol may interfere with the effects of hydroxocobalamin in the treatment of anemia by impairing bone marrow function. Contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12 in the treatment of anemia. In a group of 22 patients receiving iron dextran for iron deficiency anemia, 10 patients who also received chloramphenicol had inadequate hematologic response to the iron therapy. Four patients receiving vitamin B12 for pernicious anemia were also unresponsive to the B12 therapy while being treated with chloramphenicol. Reversible bone marrow depression is more likely to occur at higher chloramphenicol dosages that produce serum levels of 25 mcg/mL or greater.
MANAGEMENT: Patients with preexisting anemia should preferably not receive chloramphenicol due to the drug's depressive effect on bone marrow and reticulocytes. If use is unavoidable, the lowest effective dosage of chloramphenicol should be given. Hematologic response to iron or vitamin B12 therapy should be closely monitored.
- Haile CA "Chloramphenicol toxicity." South Med J 70 (1977): 479-80
- Saidi P, Wallerstein RO, Aggeler PM "Effect of chloramphenicol on erythropoiesis." J Lab Clin Med 57 (1961): 247-56
- Scott JL, Finegold SY, Belkin GA, Lawrence JS "A controlled double-blind study of the hematologic toxicity of chloramphenicol." N Engl J Med 272 (1965): 1137-42
Generic Name: chloramphenicol
Brand name:
Synonyms: Chloramphenicol, Chloramphenicol (Systemic)
Generic Name: hydroxocobalamin
Brand name: Cyanokit, Hydroxy-Cobal, Hydro-Cobex, Cobalin-H, Neo-Cytamen, Hydroxocobalamin
Synonyms: Hydroxocobalamin (injection), Hydroxocobalamin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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