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Chloramphenicol Oral, Intravenous, Injection and Iferex 150

Determining the interaction of Chloramphenicol Oral, Intravenous, Injection and Iferex 150 and the possibility of their joint administration.

Check result:
Chloramphenicol Oral, Intravenous, Injection <> Iferex 150
Relevance: 15.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Chloramphenicol may interfere with the effects of iron polysaccharide in the treatment of anemia by impairing bone marrow function. Contact your doctor if your symptoms worsen or your condition changes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Chloramphenicol can cause bone marrow depression and inhibit red blood cell maturation, which may interfere with the therapeutic effects of iron or vitamin B12 in the treatment of anemia. In a group of 22 patients receiving iron dextran for iron deficiency anemia, 10 patients who also received chloramphenicol had inadequate hematologic response to the iron therapy. Four patients receiving vitamin B12 for pernicious anemia were also unresponsive to the B12 therapy while being treated with chloramphenicol. Reversible bone marrow depression is more likely to occur at higher chloramphenicol dosages that produce serum levels of 25 mcg/mL or greater.

MANAGEMENT: Patients with preexisting anemia should preferably not receive chloramphenicol due to the drug's depressive effect on bone marrow and reticulocytes. If use is unavoidable, the lowest effective dosage of chloramphenicol should be given. Hematologic response to iron or vitamin B12 therapy should be closely monitored.

References
  • Haile CA "Chloramphenicol toxicity." South Med J 70 (1977): 479-80
  • Saidi P, Wallerstein RO, Aggeler PM "Effect of chloramphenicol on erythropoiesis." J Lab Clin Med 57 (1961): 247-56
  • Scott JL, Finegold SY, Belkin GA, Lawrence JS "A controlled double-blind study of the hematologic toxicity of chloramphenicol." N Engl J Med 272 (1965): 1137-42
Chloramphenicol Oral, Intravenous, Injection

Generic Name: chloramphenicol

Brand name:

Synonyms: Chloramphenicol, Chloramphenicol (Systemic)

Iferex 150

Generic Name: iron polysaccharide

Brand name: Ezfe, Ferrex-150, Ferus Pic-150, Iferex 150, Niferex Elixir, NovaFerrum 50, Nu-Iron 150, Poly Iron, ProFe, Myferon 150, Novaferrum, Poly-Iron, Fe-Tinic 150, Ferrex 150 Plus, Niferex-150

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.