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Chloramphenicol Oral, Intravenous, Injection and Zebutal

Determining the interaction of Chloramphenicol Oral, Intravenous, Injection and Zebutal and the possibility of their joint administration.

Check result:

Chloramphenicol Oral, Intravenous, Injection <> Zebutal

Relevance: 15.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using chloramphenicol together with butalbital may alter the effects of both medications. Contact your doctor if your condition changes or if you experience slow or shallow breathing, blurred vision, extreme drowsiness, urinating less than usual or not at all, feeling light-headed, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Barbiturates may increase the hepatic metabolism of chloramphenicol. Serum chloramphenicol levels and effectiveness may be decreased. Coadministration also may enhance the pharmacologic effect of barbiturates. The proposed mechanism is induction of chloramphenicol metabolism by barbiturates and inhibition of barbiturate metabolism by chloramphenicol.

MANAGEMENT: The effectiveness of chloramphenicol should be monitored, and plasma levels should be checked as clinically appropriate. Dosage should be increased as needed. The patient also should be monitored for barbiturate toxicity.

References

Bloxham RA, Durbin GM, Johnson T, Winterborn MH "Chloramphenicol and phenobarbitone--a drug interaction." Arch Dis Child 54 (1979): 76-7
Ambrose PJ "Clinical pharmacokinetics of chloramphenicol and chloramphenicol succinate." Clin Pharmacokinet 9 (1984): 222-38
Smith AL, Weber A "Pharmacology of chloramphenicol." Pediatr Clin North Am 30 (1983): 209-36
Palmer DL, Despopoulos A, Rael ED "Induction of chloramphenicol metabolism by phenobarbital." Antimicrob Agents Chemother 1 (1972): 112-5
Koup JR, Gibaldi M, McNamara P, et al "Interaction of chloramphenicol with phenytoin and phenobarbital." Clin Pharmacol Ther 24 (1978): 571-5
Mulhall A, de Louvois J, Hurley R "The pharmacokinetics of chloramphenicol in the neonate and young infant." J Antimicrob Chemother 12 (1983): 629-39
Kearns GL, Bocchini JA, Brown RD, et al "Absence of a pharmacokinetic interaction between chloramphenicol and acetaminophen in children." J Pediatr 107 (1985): 134-9
Krasinski K, Kusmiesz H, Nelson JD "Pharmacologic interactions among chloramphenicol, phenytoin and phenobarbital." Pediatr Infect Dis 1 (1982): 232-5

Chloramphenicol Oral, Intravenous, Injection

Generic Name: chloramphenicol

Brand name:

Synonyms: Chloramphenicol, Chloramphenicol (Systemic)

What is Chloramphenicol Oral, Intravenous, Injection?

Zebutal

Generic Name: acetaminophen / butalbital / caffeine

Brand name: Capacet, Esgic, Fioricet, Margesic, Medigesic, Orbivan, Repan, Vanatol LQ, Zebutal, Esgic-Plus, Arcet, Isocet, Pharmagesic, Anoquan, Two-Dyne, Tenake, Anolor 300, Femcet, Geone, Tencet, Triad, Fiorpap, Dolmar, Endolor, Ezol, Ide-cet, G-1, Minotal, Mygracet, Pacaps, Alagesic, Americet, Nonbac, Dolgic LQ, Dolgic Plus, Vanatol S, Alagesic LQ

Synonyms: n.a.

What is Zebutal?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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