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Chloramphenicol (Systemic) and Rifadin

Determining the interaction of Chloramphenicol (Systemic) and Rifadin and the possibility of their joint administration.

Check result:

Chloramphenicol (Systemic) <> Rifadin

Relevance: 28.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using chloramphenicol together with rifAMPin can decrease the effects of chloramphenicol. You should be monitored for an inadequate response to chloramphenicol. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Rifampin may significantly decrease the plasma concentrations of chloramphenicol by inducing its hepatic metabolism. Reduced therapeutic efficacy may occur.

MANAGEMENT: When rifampin is given concomitantly with chloramphenicol, the patient should be monitored for an inadequate response to chloramphenicol. Dosages should be adjusted as necessary.

References

Prober CG "Effect of rifampin on chloramphenicol levels." N Engl J Med 312 (1985): 788-9
Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Kelly HW, Couch RC, Davis RL, Cushing AH, Knott R "Interaction of chloramphenicol and rifampin." J Pediatr 112 (1988): 817-20
Strayhorn VA, Baciewicz AM, Self TH "Update on rifampin drug interactions, III." Arch Intern Med 157 (1997): 2453-8
"Product Information. Rifadin (rifampin)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Borcherding SM, Baciewicz AM, Self TH "Update on rifampin drug interactions." Arch Intern Med 152 (1992): 711-6

Chloramphenicol (Systemic)

Generic Name: chloramphenicol

Brand name:

Synonyms: Chloramphenicol

What is Chloramphenicol (Systemic)?

Rifadin

Generic Name: rifampin

Brand name: Rifadin, Rifadin IV, Rimactane

Synonyms: n.a.

What is Rifadin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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