Chlordiazepoxide and Sinemet 25-250
Determining the interaction of Chlordiazepoxide and Sinemet 25-250 and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:ChlordiazePOXIDE can decrease the effects of levodopa in some people. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your Parkinson symptoms worsen. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Benzodiazepines may decrease the therapeutic effects of levodopa in patients with Parkinson's disease. The mechanism is unknown.
MANAGEMENT: Patients receiving this combination should be monitored for altered clinical response. The benzodiazepine should be discontinued if an interaction is suspected.
- Hunter KR, Stern GM, Laurence DR "Use of levodopa with other drugs." Lancet 2 (1970): 1283-5
- Yosselson-Superstine S, Lipman AG "Chlordiazepoxide interaction with levodopa." Ann Intern Med 96 (1982): 259-60
- Mackie L "Drug antagonism." Br Med J 2 (1971): 651
Generic Name: chlordiazepoxide
Brand name: Librium, Libritabs, Poxi, Mitran, Formerly available as Librium
Synonyms: ChlordiazePOXIDE
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Chlordiazepoxide-Sinemet 250/25
- Chlordiazepoxide-Sinemet CR
- Chlordiazepoxide-Sinemet CR 100/25
- Chlordiazepoxide-Sinemet CR 200/50
- Chlordiazepoxide-Sinequan
- Chlordiazepoxide-Sinequan (Doxepin Capsules)
- Sinemet 25-250-Chlordiazepoxide and amitriptyline
- Sinemet 25-250-Chlordiazepoxide and clidinium
- Sinemet 25-250-Chlordiazepoxide and Clidinium Capsules
- Sinemet 25-250-Chlordiazepoxide Capsules
- Sinemet 25-250-Chlordiazepoxide hydrochloride
- Sinemet 25-250-Chlorex A