Chlordiazepoxide and clidinium and Cisatracurium Besylate
Determining the interaction of Chlordiazepoxide and clidinium and Cisatracurium Besylate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:If you are currently receiving chlordiazePOXIDE, let your doctor know before you undergo surgery that may require the use of cisatracurium or similar medications. In some cases, chlordiazePOXIDE may alter the effects of cisatracurium. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Benzodiazepines may have variable effects on nondepolarizing muscle relaxants. Potentiation, attenuation, and no effect have all been reported.
MANAGEMENT: Patients should be monitored closely for respiratory difficulty when these agents are used together.
- Feldman SA, Crawley BE "Diazepam and muscle relaxants." Br Med J 1 (1970): 691
- Driessen JJ, Crul JF, Vree TB, van Egmond J, Booij LH "Benzodiazepines and neuromuscular blocking drugs in patients." Acta Anaesthesiol Scand 30 (1986): 642-6
- Driessen JJ, Vree TB, van Egmond J, Booij LH, Crul JF "In vitro interaction of diazepam and oxazepam with pancuronium and suxamethonium." Br J Anaesth 56 (1984): 1131-8
- Stovner J, Endresen R "Intravenous anaesthesia with diazepam." Acta Anaesthesiol Scand 24 (1965): 223-7
- Driessen JJ, Vree TB, Booij LH, van der Pol FM, Crul JF "Effect of some benzodiazepines on peripheral neuromuscular function in the rat in-vitro hemidiaphragm preparation." J Pharm Pharmacol 36 (1984): 244-7
Generic Name: chlordiazepoxide / clidinium
Brand name: Librax, Clindex, Chlordinium
Synonyms: Chlordiazepoxide and Clidinium Capsules
Generic Name: cisatracurium
Brand name: Nimbex
Synonyms: Cisatracurium
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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