Chlordiazepoxide and Clidinium Capsules and Depakene (Valproic Acid Capsules)
Determining the interaction of Chlordiazepoxide and Clidinium Capsules and Depakene (Valproic Acid Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:If you are a woman of childbearing age, talk to your doctor before using valproic acid together with chlordiazePOXIDE. Combining these medications may increase the risk of harmful effects to a fetus. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: One case series has suggested that benzodiazepines may amplify the teratogenic effects of valproate in the offspring of epileptic women. Both drugs individually have been associated with adverse effects to the fetus. Another study has suggested that valproate may displace diazepam from plasma protein binding sites and inhibit its metabolism; however, the clinical significance has not been established. Other benzodiazepines may interact with valproate in a similar fashion.
MANAGEMENT: Both valproate and benzodiazepines should be avoided during pregnancy unless the potential benefits outweigh the risks to the fetus. In other patients, close observation for clinical evidence of benzodiazepine toxicity (excessive sedation) is recommended if valproate and a benzodiazepine must be used together.
- Laegreid L, Kyllerman M, Hedner T, Hagberg B, Viggedahl G "Benzodiazepine amplification of valproate teratogenic effects in children of mothers with absence epilepsy." Neuropediatrics 24 (1993): 88-92
- Dhillon S, Richens A "Valproic acid and diazepam interaction in vivo." Br J Clin Pharmacol 13 (1982): 553-60
Generic Name: chlordiazepoxide / clidinium
Brand name: Librax, Clindex, Chlordinium
Synonyms: Chlordiazepoxide and clidinium
Generic Name: valproic acid
Brand name: Depakene, Depacon, Stavzor, Valproate Sodium
Synonyms: Depakene
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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