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Chlordiazepoxide and Clidinium Capsules and Jantoven

Determining the interaction of Chlordiazepoxide and Clidinium Capsules and Jantoven and the possibility of their joint administration.

Check result:
Chlordiazepoxide and Clidinium Capsules <> Jantoven
Relevance: 15.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

One case report describes increased warfarin requirements when chlordiazepoxide was added to the regimen. However, controlled trials with many patients have not reported an interaction. Patients on oral anticoagulants should be monitored for alterations in INR whenever a change in drug regimen involves chlordiazepoxide.

References
  • Robinson DS, Sylwester D "Interaction of commonly prescribed drugs and warfarin." Ann Intern Med 72 (1970): 853-6
  • Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83
  • Orme M, Breckenridge A, Brooks RV "Interactions of benzodiazepines with warfarin." Br Med J 3 (1972): 611-4
  • Breckenridge A "Clinical implications of enzyme induction." Basic Life Sci 6 (1975): 273-301
Chlordiazepoxide and Clidinium Capsules

Generic Name: chlordiazepoxide / clidinium

Brand name: Librax, Clindex, Chlordinium

Synonyms: Chlordiazepoxide and clidinium

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.