Drug search by name

Chloromycetin Sodium Succinate and Oxacillin

Determining the interaction of Chloromycetin Sodium Succinate and Oxacillin and the possibility of their joint administration.

Check result:

Chloromycetin Sodium Succinate <> Oxacillin

Relevance: 09.12.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using chloramphenicol together with oxacillin. Combining these medications may reduce the effectiveness of oxacillin in the treatment of certain types of infections. Your doctor may prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Chloramphenicol may inhibit the bactericidal effect of penicillins when used to treat bacterial meningitis and staphylococcal endocarditis. Chloramphenicol acts by inhibiting cellular protein synthesis and can change actively growing bacteria into static ones. Since penicillins work by inhibiting cell wall synthesis, their effectiveness may be reduced. In addition, neurologic toxicity may be enhanced. Data have been conflicting, and no antagonism or synergistic effects have been reported in other types of infections.

MANAGEMENT: Until more information is available, this combination should probably be reserved for conditions where it has been found to be efficacious and avoided in situations where bactericidal activity is necessary, such as certain types of bacterial meningitis or staphylococcal endocarditis. If the combination is necessary, some experts recommend administering the penicillin several hours before the chloramphenicol. Patients should be closely monitored for altered antimicrobial efficacy.

References

Shalit I, Marks MI "Chloramphenicol in the 1980s." Drugs 28 (1984): 281-91
Wallace JF, Smith RH, Garcia M, Petersdorf RG "Studies on the pathogenesis of meningitis. VI: antagonism between penicillin and chloramphenicol in experimental pneumococcal meningitis." J Lab Clin Med 70 (1967): 408-18
Jawetz E "The use of combinations of antimicrobial drugs." Annu Rev Pharmacol 8 (1968): 151
Garrod L "Causes of failure in antibiotic treatment." Br Med J 4 (1972): 441

Chloromycetin Sodium Succinate

Generic Name: chloramphenicol

Brand name:

Synonyms: n.a.

What is Chloromycetin Sodium Succinate?

Oxacillin

Generic Name: oxacillin

Brand name: Oxacillin Sodium ADD-Vantage, Bactocill

Synonyms: Oxacillin (injection)

What is Oxacillin?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions