Chloromycetin Sodium Succinate and Tolazamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using chloramphenicol together with TOLAZamide can increase the effects of TOLAZamide, which can lead to hypoglycemia (low blood sugar). Signs and symptoms of low blood sugar include hunger, headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. You may need to check your blood sugar more often or have a dose adjustment to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The concomitant use of chloramphenicol and oral sulfonylureas may result in an enhanced hypoglycemic effect. The proposed mechanism is reduced hepatic clearance of sulfonylureas, or displacement of sulfonylureas from protein binding sites.

MANAGEMENT: Patients should be monitored for hypoglycemia when chloramphenicol is added to a sulfonylurea regimen, and for hyperglycemia when chloramphenicol is discontinued. The sulfonylurea dosage may require adjustment in affected patients. Patients receiving this combination should be advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs.

Chloromycetin Sodium Succinate

Generic Name: chloramphenicol

Brand name:

Synonyms: n.a.

What is Chloromycetin Sodium Succinate?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?