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Chloroptic and Phenytoin Sodium

Determining the interaction of Chloroptic and Phenytoin Sodium and the possibility of their joint administration.

Check result:

Chloroptic <> Phenytoin Sodium

Relevance: 13.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using chloramphenicol ophthalmic together with phenytoin. Using chloramphenicol ophthalmic with phenytoin can increase the effects of phenytoin. Symptoms of a phenytoin toxicity may include twitching eye movements, slurred speech, drowsiness, loss of balance, tremor, muscle stiffness or weakness, nausea, vomiting, feeling light-headed, fainting, and slow or shallow breathing. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Chloramphenicol often markedly increases serum phenytoin levels. Toxicity has been reported. Also, phenytoin has been reported both to increase and to decrease serum chloramphenicol levels. Significant systemic absorption of otic or ophthalmic chloramphenicol products is unlikely. However, the clinician should be aware of the possibility of a drug interaction. Similar effects may occur with other hydantoins.

MANAGEMENT: This combination usually should be avoided if possible. Patients should be closely observed for signs of hydantoin toxicity if these drugs must be given concurrently and serum phenytoin concentrations should be monitored. Patients should be advised to notify their physician if they experience symptoms of toxicity, including drowsiness, visual disturbances, change in mental status, seizures, nausea, or ataxia. The hydantoin dose may need to be decreased.

References

Saltiel M, Stephens NM "Phenytoin-chloramphenicol interaction." Drug Intell Clin Pharm 14 (1980): 221
Harper JM, Yost RL, Stewart RB, Ciezkowski J "Phenytoin-chloramphenicol interaction: a retrospective study." Drug Intell Clin Pharm 13 (1979): 425-9
Christensen LK, Skovsted L "Inhibition of drug metabolism by chloramphenicol." Lancet 2 (1969): 1397-9
Rose JQ, Choi HK, Schentag JJ, et al "Intoxication caused by interaction of chloramphenicol and phenytoin." JAMA 237 (1977): 2630-1
Powell DA, Nahata MC, Durrell DC, et al "Interactions among chloramphenicol, phenytoin, and phenobarbital in a pediatric patient." J Pediatr 98 (1981): 1001-3
Koup JR, Gibaldi M, McNamara P, et al "Interaction of chloramphenicol with phenytoin and phenobarbital." Clin Pharmacol Ther 24 (1978): 571-5
Krasinski K, Kusmiesz H, Nelson JD "Pharmacologic interactions among chloramphenicol, phenytoin and phenobarbital." Pediatr Infect Dis 1 (1982): 232-5

Chloroptic

Generic Name: chloramphenicol ophthalmic

Brand name:

Synonyms: Chloroptic (Ophthalmic)

What is Chloroptic?

Phenytoin Sodium

Generic Name: phenytoin

Brand name: Dilantin, Dilantin Infatabs, Phenytek, Phenytoin Sodium, Prompt

Synonyms: n.a.

What is Phenytoin Sodium?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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