Chloroquine and Depen

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using chloroquine together with penicillAMINE. Using these medications together can increase the effects of either medication. This can cause fever, chills, sore throat, unusual bruising or bleeding, coughing, wheezing, unexplained shortness of breath, muscle weakness, or visual disturbances. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: The concomitant use of penicillamine and chloroquine or hydroxychloroquine may potentiate the risk of hematologic and dermatologic adverse reactions due to overlapping toxicity profiles of these drugs. In addition, coadministration with chloroquine has been shown to increase the plasma concentrations of penicillamine. In six patients with rheumatoid arthritis receiving penicillamine 250 mg daily for at least three months, a single 250 mg dose of chloroquine phosphate increased the mean area under the plasma concentration-time curve of penicillamine by 52%. The mechanism of interaction has not been established.

MANAGEMENT: In general, penicillamine and chloroquine or hydroxychloroquine therapy should not be administered concurrently. Caution is advised if these drugs must be used together. Pharmacologic response to penicillamine should be monitored more closely whenever chloroquine is added to or withdrawn from therapy, and the penicillamine dosage adjusted as necessary. Patients should be advised to notify their physician if they experience signs and symptoms of toxicity such as fever, chills, sore throat, unusual bruising or bleeding, hematuria, coughing, wheezing, unexplained shortness of breath, muscle weakness, or visual disturbances.

Chloroquine

Generic Name: chloroquine

Brand name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: n.a.

What is Chloroquine?

Depen

Generic Name: penicillamine

Brand name: Cuprimine, Depen, D-Penamine, Depen Titratabs

Synonyms: n.a.

What is Depen?