Chloroquine and Oystercal-D

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

It is best not to take chloroquine and calcium carbonate at the same time. Products that contain magnesium, aluminum, or calcium such as antacids and some other gastrointestinal medications may interfere with the absorption of chloroquine and reduce its effectiveness. To minimize the risk of an interaction, you should try to separate the dosing of these medications by at least 4 hours. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Concomitant administration of antacids or kaolin may reduce the oral bioavailability of chloroquine. The proposed mechanism is adsorption of chloroquine by polyvalent cations present in these agents. Delayed dissolution of chloroquine tablets in the presence of antacids may also be a contributing factor. In six healthy study subjects, administration of a single 1 gram dose of chloroquine phosphate in combination with a 1 gram dose of magnesium trisilicate or kaolin decreased chloroquine systemic exposure (AUC) by approximately 18% and 29%, respectively, compared to administration alone. In vitro evidence of the interaction has also been reported for other antacids including calcium carbonate and gerdiga. The clinical significance has not been established.

MANAGEMENT: Chloroquine product labeling suggests separating the doses by at least 4 hours if concomitant therapy with antacids or kaolin is required. The same precaution may be applicable to hydroxychloroquine, although no data are available to support this recommendation.

Chloroquine

Generic Name: chloroquine

Brand name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: n.a.

What is Chloroquine?

Oystercal-D

Generic Name: calcium / vitamin d

Brand name: Calcitrate with D, Caltrate 600+D Soft Chews, Citracal + D, Os-Cal Extra D3, Oystercal-D, UpCal D, Os-Cal 250 with D, Oysco D, Dical-D, Calcet, Oyster Shell Calcium with Vitamin D, O-Cal-D, Oyster-D, Oyst-Cal-D, Caltro with Vitamin D, Oysco 500 with D, Oysco D with Calcium, Os-Cal with D, Caltrate 600 with D, Calcarb with D, Posture-D H/P, Dical Captabs, Dicalphos plus D, Os-Cal 500 with D, Caltrate 600 with D Plus Soy, Caltrate Colon Health, Calvite P & D, Sedecal D, Chewable Calcium with Vitamin D, Osteocit D Plus, Os-Cal 500 + D, Citracal Petites, Citracal Creamy Bites, Citracal 250 mg + D, Calcio Del Mar, Citrus Calcium with Vitamin D, Calcium 600+D, Risacal-D, Liquid Calcium with Vitamin D, Citracal Maximum + D, Citracal Calcium + D Slow Release 1200, Citracal Calcium Gummies, Caltrate Gummy Bites, Super Calcium 600 + D3 400, Os-Cal Calcium+D3, Caltrate 600 + D, Citracal Regular, Calcet Petites, Calcium 500+D, D3 with Calcium, Calcitrate, Caltrate 600+D, Os-Cal 500+D, Os-Cal 500+Extra D Chewable

Synonyms: n.a.

What is Oystercal-D?