Chloroquine Oral, Intramuscular and Gengraf Capsules

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Chloroquine may increase the blood levels and effects of cycloSPORINE. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, seizures, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with chloroquine may increase the serum concentrations of cyclosporine. The mechanism of interaction has not been established. Two case reports described increases of nearly 3- and 4.5-fold in cyclosporine levels shortly after the initiation of chloroquine therapy, with one occurring within 2 days of starting chloroquine 900 mg/day and the other within 6 days of starting chloroquine 100 mg/day. Both patients had increased serum creatinine levels and one had elevated blood pressure, which resolved following the discontinuation of chloroquine. In one case, the interaction was confirmed upon reinitiation of chloroquine.

MANAGEMENT: Until more information is available, caution is advised if cyclosporine is used in combination with chloroquine. Cyclosporine blood levels and renal function should be checked frequently and the dosage adjusted accordingly, particularly following the initiation or discontinuation of chloroquine. Patients should be advised to notify their physician if they experience possible signs of cyclosporine toxicity such as nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, headache, tremors, and convulsions

Chloroquine Oral, Intramuscular

Generic Name: chloroquine

Brand name: Aralen Phosphate, Aralen Hydrochloride

Synonyms: Chloroquine

What is Chloroquine Oral, Intramuscular?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?