Chlorothiazide Injection and Irinotecan Hydrochloride
Determining the interaction of Chlorothiazide Injection and Irinotecan Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using irinotecan together with chlorothiazide may increase the risk of dehydration and electrolyte abnormalities. Irinotecan can cause severe vomiting and diarrhea, which leads to water and electrolyte loss from the body that may be worsened with the use of a diuretic. Talk to your doctor if you have any questions or concerns. You should seek prompt medical attention if you experience vomiting or diarrhea that is not responsive to medications. In severe cases, dehydration and electrolyte abnormalities can lead to irregular heart rhythm, seizures, and kidney problems. Contact your doctor if you experience potential signs and symptoms of fluid and electrolyte depletion such as dizziness, lightheadedness, dry mouth, thirst, fatigue, weakness, muscle cramps, decreased urination, palpitation, and increased heart rate. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Irinotecan-induced vomiting or diarrhea may increase the risk and/or severity of dehydration produced by diuretics.
MANAGEMENT: Concomitant use of diuretics during irinotecan administration or during periods of vomiting or diarrhea that may follow is not recommended.
- "Product Information. Camptosar (irinotecan)." Pharmacia and Upjohn, Kalamazoo, MI.
Generic Name: chlorothiazide
Brand name: Diuril, Diuril Sodium
Synonyms: Chlorothiazide (oral/injection), Chlorothiazide
Generic Name: irinotecan
Brand name: Camptosar
Synonyms: Irinotecan (Conventional), Irinotecan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Chlorothiazide Injection-Irinotecan Intravenous
- Chlorothiazide Injection-Irinotecan liposomal
- Chlorothiazide Injection-Irinotecan liposome Intravenous
- Chlorothiazide Injection-Iron 100/C
- Chlorothiazide Injection-Iron 21/7
- Chlorothiazide Injection-Iron and Docusate
- Irinotecan Hydrochloride-Chlorothiazide Intravenous
- Irinotecan Hydrochloride-Chlorothiazide oral/injection
- Irinotecan Hydrochloride-Chlorothiazide Sodium
- Irinotecan Hydrochloride-Chlorothiazide Suspension
- Irinotecan Hydrochloride-Chlorothiazide Tablets
- Irinotecan Hydrochloride-Chlorphen Mal, Dex HBr, Pseudoeph