Chlorothiazide Intravenous and Methotrexate Sodium
Determining the interaction of Chlorothiazide Intravenous and Methotrexate Sodium and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Before taking methotrexate, tell your doctor if you also use chlorothiazide. You may need dose adjustments or special tests in order to safely take both medications together. Your blood work may need to be monitored more frequently or using a different blood pressure medicine may be necessary. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using your medications without first talking to your doctor first.
Professional:MONITOR: Antineoplastic-induced bone marrow suppression may be prolonged with concomitant thiazide administration. The mechanism is unknown. Thiazides have been associated with blood dyscrasias.
MANAGEMENT: Alternative antihypertensive therapy may be advisable. Hematological status should be closely monitored in patients receiving this combination.
- Kristensen LO, Weismann K, Hutters L "Renal function and the rate of disappearance of methotrexate from serum." Eur J Clin Pharmacol 8 (1975): 439-44
- Hardman JG, Gilman AG, Limbird LE eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 9th ed." New York, NY: McGraw-Hill (1995):
- Orr LE "Potentiation of myelosuppression from cancer chemotherapy and thiazide diuretics." Drug Intell Clin Pharm 15 (1981): 967-70
Generic Name: chlorothiazide
Brand name: Diuril, Diuril Sodium
Synonyms: Chlorothiazide (oral/injection), Chlorothiazide
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: Methotrexate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Chlorothiazide Intravenous-Methotrexate Tablets
- Chlorothiazide Intravenous-Methoxsalen
- Chlorothiazide Intravenous-Methoxsalen (Systemic)
- Chlorothiazide Intravenous-Methoxsalen (Topical)
- Chlorothiazide Intravenous-Methoxsalen Extracorporeal Solution
- Chlorothiazide Intravenous-Methoxsalen Hard-Gelatin Capsules
- Methotrexate Sodium-Chlorothiazide oral/injection
- Methotrexate Sodium-Chlorothiazide Sodium
- Methotrexate Sodium-Chlorothiazide Suspension
- Methotrexate Sodium-Chlorothiazide Tablets
- Methotrexate Sodium-Chlorphen Mal, Dex HBr, Pseudoeph
- Methotrexate Sodium-Chlorphen Mal, Pseudoeph HCl