Chlorpheniramine and Acetaminophen and Imodium A-D EZ Chews
Determining the interaction of Chlorpheniramine and Acetaminophen and Imodium A-D EZ Chews and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using loperamide together with chlorpheniramine may increase side effects such as dizziness, drowsiness, and difficulty concentrating. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Chlorpheniramine may also increase the effects of loperamide on your intestines. Contact your doctor if you experience abdominal cramping or bloating during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration with drugs that possess significant anticholinergic activity may potentiate the antimotility effect of loperamide. An isolated case report describes an incident of fatal gastroenteritis during concomitant treatment with clozapine and loperamide. A 36-year-old man who had been treated with clozapine 500 mg/day and was previously in good health died after taking a total of 6 mg of loperamide during an outbreak of intestinal disease in a Finnish hospital. The patient received no other medications. The authors theorized that the anticholinergic effect of clozapine in combination with the antimotility effect of loperamide may have led to toxic megacolon. However, causality has not been determined.
MANAGEMENT: Until further information is available, loperamide should be used with caution in combination with drugs that possess significant anticholinergic activity (e.g., antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; class IA antiarrhythmics especially disopyramide). Ambulatory patients should also be made aware of the possibility of additive CNS effects (e.g., drowsiness, dizziness, lightheadedness, confusion) and counseled to avoid activities requiring mental alertness until they know how these agents affect them.
- Eronen M, Putkonen H, Hallikainen T, Vartiainen H "Lethal gastroenteritis associated with clozapine and loperamide." Am J Psychiatry 160 (2003): 2242-2243
Generic Name: acetaminophen / chlorpheniramine
Brand name: Coricidin, Coricidin HBP Cold & Flu
Synonyms: Acetaminophen and chlorpheniramine
Generic Name: loperamide
Brand name: Diamode, Imodium A-D, Anti-Diarrheal [OTC], Imodium A-D EZ Chews, Imodium A-D New Formula, Imodium, Maalox Anti-Diarrheal, Pepto Diarrhea Control, Imotil, Kao-Paverin, Kaopectate 1-D, Diar-Aid
Synonyms: Imodium A-D
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Chlorpheniramine and Acetaminophen-Imodium A-D New Formula
- Chlorpheniramine and Acetaminophen-Imodium Multi-Symptom Relief
- Chlorpheniramine and Acetaminophen-Imogam Rabies-HT
- Chlorpheniramine and Acetaminophen-Imogam Rabies-HT human
- Chlorpheniramine and Acetaminophen-Imogen
- Chlorpheniramine and Acetaminophen-Imotil
- Imodium A-D EZ Chews-Chlorpheniramine and codeine
- Imodium A-D EZ Chews-Chlorpheniramine and codeine polistirex
- Imodium A-D EZ Chews-Chlorpheniramine and dextromethorphan
- Imodium A-D EZ Chews-Chlorpheniramine and hydrocodone
- Imodium A-D EZ Chews-Chlorpheniramine and phenylephrine
- Imodium A-D EZ Chews-Chlorpheniramine and Phenylephrine Liquid