Chlorpheniramine, phenylephrine, and pyrilamine and Dipivefrin Hydrochloride

• Generic Name: chlorpheniramine / phenylephrine / pyrilamine
• Dosage Forms: n.a.
• Other Brand Names: Chlorex-A 12, Conal, MyHist-PD, Nalex A 12, Phena-Plus, Phena-S, Poly Hist PD, Ru-Hist Forte, Atrohist Pediatric, Rynatan-S Pediatric, R-Tannate Pediatric, Gelhist Pediatric, R-Tannate, Triotann-S, R-Tannamine Pediatric, Triotann-S Pediatric, Tanoral Pediatric, Equitan Pediatric, Triple Tannate Pediatric, Tri-Tannate, Tanamine Pediatric, Tri-Tannate Pediatric, Rhinatate Pediatric, Rhinatate, Url-Tannate Pediatric, Tritan, Tanamine, R-Tannamine, Tanoral, URL-Tannate, Triotann, Histatan, Triotann Pediatric, Tri-Gestan S, Tri-Hist Pediatric, Tri Tann Pediatric, Poly Hist Forte, AllerTan, Triplex AD

Chlorpheniramine and pyrilamine are antihistamines that reduce the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Chlorpheniramine, phenylephrine, and pyrilamine is a combination medicine used to treat runny or stuffy nose, sneezing, itching, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Chlorpheniramine, phenylephrine, and pyrilamine may also be used for purposes not listed in this medication guide.

• Generic Name: dipivefrin ophthalmic
• Dosage Forms: n.a.
• Other Brand Names: Propine

Reduction of elevated IOP in patients with open-angle glaucoma. Used alone or in conjunction with other IOP-lowering drugs. May be used as initial therapy or for control of IOP in those patients who have not responded adequately to other antiglaucoma agents.

May be preferred as an alternative to topical epinephrine in some patients (e.g., those with cardiovascular disease) because of increased intraocular penetration (lower doses are needed) and resultant decreased adverse systemic effects (e.g., cardiovascular effects) compared with epinephrine.

Does not produce miosis, accommodative spasm, blurred vision, or night blindness. Less likely than epinephrine to cause adenochrome staining of contact lenses.

Has been used to reduce IOP in the treatment of other ocular conditions, including ocular hypertension and pseudoexfoliative, low-tension, and secondary (e.g., post-angle closure, pigmentary, traumatic, herpes zoster) glaucomas.