Chlorpromazine Hydrochloride and Cimetidine Tablets
Determining the interaction of Chlorpromazine Hydrochloride and Cimetidine Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited evidence suggests that cimetidine may reduce the therapeutic effects of chlorpromazine. Tailoring of chlorpromazine dosage may be necessary.
- Howes CA, Pullar T, Sourindhrin I, et al "Reduced steady-state plasma concentrations of chlorpromazine and indomethacin in patients receiving cimetidine." Eur J Clin Pharmacol 24 (1983): 99-102
- Byrne A, O'Shea B "Adverse interaction between cimetidine and chlorpromazine in two cases of chronic schizophrenia." Br J Psychiatry 155 (1989): 413-5
Generic Name: chlorpromazine
Brand name: Ormazine, Thorazine, Thorazine Spansule
Synonyms: Chlorpromazine, ChlorproMAZINE
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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