Chlorpromazine Hydrochloride and Enasidenib Mesylate

• Generic Name: chlorpromazine
• Dosage Forms: n.a.
• Other Brand Names:

  Ormazine, Thorazine, Thorazine Spansule

Symptomatic management of psychotic disorders (i.e., schizophrenia).

Management of nausea and vomiting, including during surgery.

Relief of restlessness and apprehension before surgery.

Treatment of acute intermittent porphyria.

Adjunct in the treatment of tetanus.

Symptomatic management of manic phase of bipolar disorder.

Treatment of intractable hiccups.

Treatment of severe behavioral problems in children marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations).

Short-term treatment of hyperactive children who exhibit excessive motor activity with accompanying conduct disorders manifested as impulsivity, difficulty sustaining attention, aggression, mood lability, and/or poor frustration tolerance.

• Generic Name: enasidenib
• Dosage Forms: n.a.
• Other Brand Names: Idhifa, Idhifa

For the treatment of relapsed or refractory AML with IDH2 mutation (designated an orphan drug by FDA for this use).

FDA-approved diagnostic test (e.g., Abbott RealTime IDH2 assay) required to confirm the presence of IDH2 mutation prior to initiation of therapy.