Chlorpromazine Hydrochloride and Thiotepa Injection

• Generic Name: chlorpromazine
• Dosage Forms: n.a.
• Other Brand Names:

  Ormazine, Thorazine, Thorazine Spansule

Symptomatic management of psychotic disorders (i.e., schizophrenia).

Management of nausea and vomiting, including during surgery.

Relief of restlessness and apprehension before surgery.

Treatment of acute intermittent porphyria.

Adjunct in the treatment of tetanus.

Symptomatic management of manic phase of bipolar disorder.

Treatment of intractable hiccups.

Treatment of severe behavioral problems in children marked by combativeness and/or explosive hyperexcitable behavior (out of proportion to immediate provocations).

Short-term treatment of hyperactive children who exhibit excessive motor activity with accompanying conduct disorders manifested as impulsivity, difficulty sustaining attention, aggression, mood lability, and/or poor frustration tolerance.

• Generic Name: thiotepa
• Dosage Forms: n.a.
• Other Brand Names: Thioplex, Tepadina

Thiotepa injection is used to lower risk of graft rejection when used with other medicines (eg, high-dose busulfan, cyclophosphamide) as a preparative regimen for stem cell transplantation in children with class 3 beta-thalassemia. It is also used to treat cancer of the breast, ovary, and urinary bladder. Thiotepa is also used to treat malignant effusions (accumulation of fluid in the body cavity) caused by cancer.

Thiotepa belongs to the group of medicines called alkylating agents. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by thiotepa, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects do not occur for months or years after the medicine is used.

Thiotepa is to be given only by or under the immediate supervision of your doctor.