Drug search by name

Chlorpromazine Hydrochloride and Zovia 1/50e

Determining the interaction of Chlorpromazine Hydrochloride and Zovia 1/50e and the possibility of their joint administration.

Check result:

Chlorpromazine Hydrochloride <> Zovia 1/50e

Relevance: 26.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using chlorproMAZINE together with ethinyl estradiol may increase the effects of chlorproMAZINE. Contact your doctor if you experience tremor, uncontrollable movements, or excessive sedation. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: High chlorpromazine plasma concentrations and toxicity have been reported during concomitant use of an oral contraceptive. Chlorpromazine levels increased six-fold (from 134 ng/mL to 838 ng/mL) approximately one week after a patient started taking an ethinyl estradiol-norgestrel combination contraceptive, and she experienced tremors and severe dyskinesias. The mechanism is unknown but inhibition of CYP450 metabolism or effects on P-glycoprotein transport by contraceptive hormones have been suggested. Causality was not clearly determined.

MANAGEMENT: Until more information is available, monitoring for signs and symptoms of chlorpromazine toxicity when oral contraceptives are added to the regimen is recommended. Patients should be advised to notify their physician if they experience symptoms such as tremor, dyskinesias, or excessive sedation.

References

Chetty M, Miller R "Oral contraceptives increase the plasma concentrations of chlorpromazine." Ther Drug Monit 23 (2001): 556-8

Chlorpromazine Hydrochloride

Generic Name: chlorpromazine

Brand name: Ormazine, Thorazine, Thorazine Spansule

Synonyms: Chlorpromazine, ChlorproMAZINE

What is Chlorpromazine Hydrochloride?

Zovia 1/50e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50, Zovia 1/50E

What is Zovia 1/50e?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions