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Chlorpromazine Tablets and Depakote Sprinkles

Determining the interaction of Chlorpromazine Tablets and Depakote Sprinkles and the possibility of their joint administration.

Check result:

Chlorpromazine Tablets <> Depakote Sprinkles

Relevance: 06.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using chlorproMAZINE together with divalproex sodium can increase the effects of divalproex sodium. Contact your doctor if you experience weakness, fatigue, confusion, loss of muscle coordination, increased seizures, nausea, or vomiting. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Chlorpromazine may decrease the plasma clearance of valproate and increase serum levels. Valproate toxicity may result. Cases of severe nephrotoxicity have been reported.

MANAGEMENT: Close clinical and laboratory monitoring for evidence of valproate toxicity is recommended during concomitant therapy. Patients should be advised to notify their physicians if they experience weakness, fatigue, confusion, ataxia, increased seizures, nausea, or vomiting.

References

Vestal RE, Kornhauser DM, Hollifield JW, Shand DG "Inhibition of propranolol metabolism by chlorpromazine." Clin Pharmacol Ther 25 (1979): 19-24
Miller F, Rampling D "Adverse effects of combined propranolol and chlorpromazine therapy." Am J Psychiatry 139 (1982): 1198-9
Ishizaki T, Chiba K, Saito M, et al "The effects of neuroleptics (haloperidol and chlorpromazine) on the pharmacokinetics of valproic acid in schizophrenic patients." J Clin Psychopharmacol 4 (1984): 254-61
Peet M, Middlemiss D, Yates R "Pharmacokinetic interaction between propranolol and chlorpromazine in schizophrenic patients." Lancet 2 (1980): 978
Bach N, Thung SN, Schaffner F, Tobias H "Exaggerated cholestasis and hepatic fibrosis following simultaneous administration of chlorpromazine and sodium valproate." Dig Dis Sci 34 (1989): 1303-7
Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9
Silver JM, Yudofsky SC, Kogan M, Katz BL "Elevation of thioridazine plasma levels by propranolol." Am J Psychiatry 143 (1986): 1290-2

Chlorpromazine Tablets

Generic Name: chlorpromazine

Brand name: Ormazine, Thorazine, Thorazine Spansule

Synonyms: Chlorpromazine, ChlorproMAZINE

What is Chlorpromazine Tablets?

Depakote Sprinkles

Generic Name: divalproex sodium

Brand name: Depakote ER, Depakote Sprinkles, Depakene, Depacon, Depakote

Synonyms: Depakote Capsules

What is Depakote Sprinkles?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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