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Chlorpromazine Tablets and InnoPran XL

Determining the interaction of Chlorpromazine Tablets and InnoPran XL and the possibility of their joint administration.

Check result:

Chlorpromazine Tablets <> InnoPran XL

Relevance: 06.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using propranolol together with chlorproMAZINE can increase the blood levels or add to the side effects of either medication. Contact your doctor if you experience decrease in blood pressure or heart rate, delirium or seizures. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Some antipsychotic agents and some beta-blockers may mutually inhibit each other's metabolism resulting in increased or additive pharmacologic effects such as hypotension, bradycardia, delirium or seizures. The mechanism may be related to competitive inhibition of CYP450 2D6-mediated first-pass metabolism.

MANAGEMENT: Atenolol, carteolol, or nadolol may be considered as alternatives because they undergo renal elimination and are not expected to interact. If this combination cannot be avoided, decreased dosage of either or both drugs may be necessary and the patient should be closely monitored for cardiovascular or nervous system adverse effects.

References

Silver JM, Yudofsky SC, Kogan M, Katz BL "Elevation of thioridazine plasma levels by propranolol." Am J Psychiatry 143 (1986): 1290-2
Peet M, Middlemiss D, Yates R "Pharmacokinetic interaction between propranolol and chlorpromazine in schizophrenic patients." Lancet 2 (1980): 978
Markowitz JS, Wells BG, Carson WH "Interactions between antipsychotic and antihypertensive drugs." Ann Pharmacother 29 (1995): 603-9
Vestal RE, Kornhauser DM, Hollifield JW, Shand DG "Inhibition of propranolol metabolism by chlorpromazine." Clin Pharmacol Ther 25 (1979): 19-24
Miller F, Rampling D "Adverse effects of combined propranolol and chlorpromazine therapy." Am J Psychiatry 139 (1982): 1198-9

Chlorpromazine Tablets

Generic Name: chlorpromazine

Brand name: Ormazine, Thorazine, Thorazine Spansule

Synonyms: Chlorpromazine, ChlorproMAZINE

What is Chlorpromazine Tablets?

InnoPran XL

Generic Name: propranolol

Brand name: Hemangeol, Inderal LA, Inderal XL, InnoPran XL, Inderal, InnoPran XL

Synonyms: n.a.

What is InnoPran XL?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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