Cholbam and Gengraf (Cyclosporine Oral Solution, Modified)
Determining the interaction of Cholbam and Gengraf (Cyclosporine Oral Solution, Modified) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:CycloSPORINE may reduce the effectiveness of cholic acid in treating your condition. Talk to you doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with inhibitors of the bile salt efflux pump (BSEP) may exacerbate accumulation of conjugated bile salts in the liver and lead to clinical symptoms in patients treated with cholic acid.
MANAGEMENT: Concomitant use of cholic acid with drugs that inhibit canalicular membrane bile acid transporters such as the BSEP should generally be avoided. If coadministration is required, close monitoring of serum transaminases and bilirubin is recommended. In addition, serum and urine bile acid levels should be monitored, and the cholic acid dose adjusted accordingly.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Cholbam (cholic acid)." Manchester Pharmaceutical, Fort Collins, CO.
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Gengraf (Capsules, Modified), Gengraf
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cholbam-Gengraf Capsules
- Cholbam-Gengraf Oral
- Cholbam-Gengraf Oral Solution
- Cholbam-Genicin
- Cholbam-Genicin Vita-Q
- Cholbam-Genotropin
- Gengraf (Cyclosporine Oral Solution, Modified)-Cholecalciferol
- Gengraf (Cyclosporine Oral Solution, Modified)-Cholecalciferol and folic acid
- Gengraf (Cyclosporine Oral Solution, Modified)-Cholecalciferol Capsules and Tablets
- Gengraf (Cyclosporine Oral Solution, Modified)-Cholecalciferol Chewable Tablet
- Gengraf (Cyclosporine Oral Solution, Modified)-Cholecalciferol Drops
- Gengraf (Cyclosporine Oral Solution, Modified)-Cholecalciferol Orally Disintegrating Tablets