Cholbam and Niraparib Tosylate

• Generic Name: cholic acid
• Dosage Forms: capsule
• Other Brand Names: Cholbam

Cholbam is a bile acid. Bile acids are produced naturally in the body to aid in digestion of fats and certain nutrients.

People with bile acid disorders are unable to produce Cholbam normally. This can make it harder for the body to absorb nutrients important for health, growth, and body functioning. Abnormal bile acids can also build up in the body and become toxic to the liver.

Cholbam is used in people with bile acid disorders. Cholbam works by normalizing bile acid production in the body.

Cholbam may also be used for purposes not listed in this medication guide.

• Generic Name: niraparib
• Dosage Forms: n.a.
• Other Brand Names: Zejula

Maintenance therapy of recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer in patients in complete or partial response following platinum-based chemotherapy (designated an orphan drug by FDA for this use).

In the principal efficacy study (NOVA), niraparib maintenance therapy substantially prolonged progression-free survival in patients with platinum-sensitive epithelial ovarian, fallopian tube, or primary peritoneal cancer compared with placebo regardless of the presence or absence of germline BRCA mutations or homologous recombination deficiency (HRD) status.