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Cholbam and Phenobarbital Elixir

Determining the interaction of Cholbam and Phenobarbital Elixir and the possibility of their joint administration.

Check result:
Cholbam <> Phenobarbital Elixir
Relevance: 02.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

PHENobarbital may reduce the effectiveness of cholic acid in treating your condition. Talk to you doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration of phenobarbital with cholic acid may decrease the therapeutic effects of cholic acid. The mechanism of this interaction has not been delineated.

MANAGEMENT: The use of phenobarbital with cholic acid in patients with 3-beta-hydroxy delta-5 C27-steroid oxidoreductase deficiency or delta-4 3-oxosteroid 5-beta-reductase deficiency should generally be avoided. However, some authorities consider use of phenobarbital with cholic acid in this patient population as contraindicated.

References
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cholbam

Generic Name: cholic acid

Brand name: Cholbam

Synonyms: n.a.

Phenobarbital Elixir

Generic Name: phenobarbital

Brand name: Solfoton, Luminal

Synonyms: Phenobarbital, PHENobarbital

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction