Cholecalciferol and folic acid and Rheumatrex Dose Pack
Determining the interaction of Cholecalciferol and folic acid and Rheumatrex Dose Pack and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Folic acid may reduce the effects of methotrexate. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of methotrexate with vitamin preparations containing folic acid, folinic acid (leucovorin) or their derivatives may diminish the therapeutic effects of methotrexate. The proposed mechanism involves pharmacodynamic antagonism and/or competitive inhibition at the receptor site.
MANAGEMENT: Although folic acid or folinic acid are frequently used along with methotrexate to reduce adverse effects or as an antidote to high dose methotrexate therapy, patients receiving methotrexate should be advised to avoid the inadvertent use of vitamin preparations containing folic acid or its derivatives.
- "Product Information. Methotrexate Sodium (methotrexate)." Teva Pharmaceuticals (formerly IVAX), Miami, FL.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: cholecalciferol / folic acid
Brand name: Ortho D, Zolate, Ortho DF, Genicin Vita-D
Synonyms: n.a.
Generic Name: methotrexate
Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free
Synonyms: Rheumatrex
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cholecalciferol and folic acid-Rheumatrex Dose Pack Oral
- Cholecalciferol and folic acid-Rhinall
- Cholecalciferol and folic acid-Rhinocort
- Cholecalciferol and folic acid-Rhinocort Allergy
- Cholecalciferol and folic acid-Rhinocort Aqua
- Cholecalciferol and folic acid-Rhinocort Aqua eent
- Rheumatrex Dose Pack-Cholecalciferol Capsules and Tablets
- Rheumatrex Dose Pack-Cholecalciferol Chewable Tablet
- Rheumatrex Dose Pack-Cholecalciferol Drops
- Rheumatrex Dose Pack-Cholecalciferol Orally Disintegrating Tablets
- Rheumatrex Dose Pack-Cholecalciferol Sublingual Spray
- Rheumatrex Dose Pack-Cholecalciferol Wafer