Choledyl Expectorant Elixir and Ketamine Intramuscular, Intravenous
Determining the interaction of Choledyl Expectorant Elixir and Ketamine Intramuscular, Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using ketamine together with oxtriphylline may cause seizures. Contact your doctor if you experience confusion, seizures, and other mental status changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Cases of extensor-type seizures have been reported in four asthmatic patients who received aminophylline following induction of anesthesia with ketamine. Causality was not clearly determined due to the presence of other anesthetics. Animal studies suggest that the mechanism of this interaction may involve a lowering of the seizure threshold. Theophylline, dyphylline, and oxtriphylline may also interact.
MANAGEMENT: If aminophylline and ketamine must be used concomitantly, caution should be exercised.
- Hirshman CA, Krieger W, Littlejohn G, Lee R, Julien R "Ketamine-aminophylline-induced decrease in seizure threshold." Anesthesiology 56 (1982): 464-7
Generic Name: guaifenesin / oxtriphylline
Brand name:
Synonyms: Oxtriphylline and guaifenesin (Oral)
Generic Name: ketamine
Brand name: Ketalar
Synonyms: Ketamine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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