Choledyl Expectorant Elixir and Levothyroxine Injection Solution
Determining the interaction of Choledyl Expectorant Elixir and Levothyroxine Injection Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using levothyroxine together with oxtriphylline may alter the effects of oxtriphylline. When levothyroxine is started, stopped, or changed you should be monitored for an altered response to your oxtriphylline medication. Contact your doctor if you experience a worsening of breathing symptoms, or any signs of oxtriphylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeats. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The metabolism of theophylline is directly related to thyroid function. Theophylline clearance is decreased in hypothyroid patients and increased in hyperthyroid patients. Toxicity or subtherapeutic levels may occur. Similar interactions may occur with other methylxanthines.
MANAGEMENT: When thyroid hormone dosage is instituted, discontinued, or changed, close observation for altered theophylline effect and serum concentrations is recommended. Patients should be advised to notify their physician if they experience a worsening of their respiratory symptoms, or any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeats.
- Bauman JH, Teichman S, Wible DA "Increased theophylline clearance in a patient with hyperthyroidism." Ann Allergy 52 (1984): 94-6
- Vozeh S, Otten M, Staub JJ, Follath F "Influence of thyroid function on theophylline kinetics." Clin Pharmacol Ther 36 (1984): 634-40
Generic Name: guaifenesin / oxtriphylline
Brand name:
Synonyms: Oxtriphylline and guaifenesin (Oral)
Generic Name: levothyroxine
Brand name: Levoxyl, Synthroid, Tirosint, Unithroid, Euthyrox, Levothroid, Tirosint-Sol
Synonyms: Levothyroxine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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