Choledyl Expectorant Elixir and Terbinafine Tablets
Determining the interaction of Choledyl Expectorant Elixir and Terbinafine Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using terbinafine together with oxtriphylline may increase the effects of oxtriphylline. You should contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or an irregular heartbeat. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The coadministration of terbinafine and theophylline may result in elevated plasma concentrations of the latter. In a randomized, crossover study consisting of 12 healthy volunteers, terbinafine (250 mg orally once a day for 4 days) increased the area under the serum concentration-time curve (AUC) and half-life of a single dose of theophylline (5 mg/kg) by 16% and 24%, respectively, compared to placebo. Oral clearance decreased by 14%. The exact mechanism is unknown but may involve inhibition of the CYP450 1A2 enzymatic pathway, which is responsible for the metabolism of theophylline and other methylxanthines such as caffeine, the clearance of which has also been found to be reduced (21%) by terbinafine.
MANAGEMENT: Given the narrow therapeutic index of theophylline, patients should be monitored closely during concomitant therapy with terbinafine. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever terbinafine is added to or withdrawn from therapy. Due to the long elimination half-life of terbinafine, especially following prolonged use, potential drug interactions may be observed for several months after discontinuation of terbinafine therapy. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.
- Trepanier EF, Nafziger AN, Amsden GW "Effect of terbinafine on theophylline pharmacokinetics in healthy volunteers." Antimicrob Agents Chemother 42 (1998): 695-7
- Wahllander A, Paumgartner G "Effect of ketoconazole and terbinafine on the pharmacokinetics of caffeine in healthy volunteers." Eur J Clin Pharmacol 37 (1989): 279-83
Generic Name: guaifenesin / oxtriphylline
Brand name:
Synonyms: Oxtriphylline and guaifenesin (Oral)
Generic Name: terbinafine
Brand name: Lamisil, Terbinex
Synonyms: Terbinafine, Terbinafine (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Choledyl Expectorant Elixir-Terbinafine Tablets and Hydroxypropyl-Chitosan Nail Lacquer
- Choledyl Expectorant Elixir-Terbinex
- Choledyl Expectorant Elixir-Terbutaline
- Choledyl Expectorant Elixir-Terbutaline Injection
- Choledyl Expectorant Elixir-Terbutaline Subcutaneous
- Choledyl Expectorant Elixir-Terbutaline Sulfate
- Terbinafine Tablets-Cholera vaccine
- Terbinafine Tablets-Cholera Vaccine Live Oral
- Terbinafine Tablets-Cholestyramine
- Terbinafine Tablets-Cholestyramine Light
- Terbinafine Tablets-Cholestyramine Resin
- Terbinafine Tablets-Choletec