Cholestyramine and Flagyl 375

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cholestyramine together with metroNIDAZOLE may decrease the effects of metroNIDAZOLE. It may be appropriate to separate dosing of cholestyramine and metroNIDAZOLE. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Cholestyramine may bind to and decrease the oral bioavailability of nitroimidazoles. Data are limited. An in vitro study found no physicochemical interaction between metronidazole and cholestyramine when mixed in solution at pH 7.38 at various ratios. However, the bioavailability of metronidazole was reduced by 21% during coadministration with a 4 gram dose of cholestyramine in five healthy subjects. No data are available for tinidazole.

MANAGEMENT: To minimize the potential for interaction, patients should be advised to separate the times of administration of cholestyramine and the nitroimidazole by at least several hours.

Cholestyramine

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: Cholestyramine Resin

What is Cholestyramine?

Flagyl 375

Generic Name: metronidazole

Brand name: FIRST Metronidazole, Flagyl, Flagyl 375, MetroGel

Synonyms: Flagyl 375 Capsules

What is Flagyl 375?