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Cholestyramine and Silenor

Determining the interaction of Cholestyramine and Silenor and the possibility of their joint administration.

Check result:

Cholestyramine <> Silenor

Relevance: 05.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cholestyramine may interfere with the absorption of oral tricyclic antidepressants, resulting in a moderate reduction of antidepressant serum concentrations. The clinical significance is unknown. The effectiveness of tricyclic antidepressants may be reduced. Monitoring the patient for altered therapeutic effects may be advisable. If an interaction is suspected, tricyclic antidepressants should be administered at least two hours before or four to six hours after cholestyramine.

References

Spina E, Avenoso A, Campo GM, Caputi AP, Perucca E "Decreased plasma concentrations of imipramine and desipramine following cholestyramine intake in depressed patients." Ther Drug Monit 16 (1994): 432-4
Bailey DN, Coffee JJ, Anderson B, Manoguerra AS "Interaction of tricyclic antidepressants with cholestyramine in vitro." Ther Drug Monit 14 (1992): 339-42

Cholestyramine

Generic Name: cholestyramine

Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets

Synonyms: Cholestyramine Resin

What is Cholestyramine?

Silenor

Generic Name: doxepin

Brand name: Silenor, Sinequan, Sinequan

Synonyms: n.a.

What is Silenor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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